And I will put enmity between thee and the woman, and between thy seed and her seed; it [he] shall bruise thy head, and thou shalt bruise his heel.” — Genesis 3:15

In this powerful prophecy of Christ right from the Garden of Eden, we see the future battle between Satan and God, and the victory of his Son.  Note that God tells the serpent Satan that he shall put enmity (“Mutual hatred or ill will“) between the Devil and “her” seed.  This denotes the fact that Christ will come, not of man’s seed but of God; thus it would not be Joseph’s seed, and could be called Mary’s seed.

In the entire bible the phrase “her seed” is used exactly twice — here and in the Book of Revelations, where again, the war between Satan and “her seed” (followers of Christ) is still taking place:

And the dragon [Satan] was wroth with the woman, and went to
make war with the remnant of her seed, which keep the commandments of God, and have the testimony of Jesus Christ.

In the book of Isaiah we read of this prophecy again:

Therefore the Lord himself shall give you a sign; Behold, a
virgin shall conceive, and bear a son, and shall call his name
Immanuel.” — Isaiah 7:14

Matthew references this very verse:

Behold, a virgin shall be with child, and shall bring forth a son, and they shall call his name Emmanuel, which being interpreted is, God with us.” — Matthew 1:23

The word Emmanuel (or Immanuel) literally means “God is with us

Paul, in his letter to the Galatians, stated:

But when the fulness of the time was come, God sent forth his Son, made of a woman, made under the law,” — Gal 4:4

In Luke, when Mary is visited  by Gabriel she wonders how this miracle of her carrying the Christ is possible:

{1:31} And, behold,  thou shalt conceive in thy womb, and bring forth a son, and shalt call his name JESUS. {1:32} He shall be great, and shall be called the Son of the Highest: and the Lord God shall give unto him the throne of his father David: {1:33} And he shall reign over the house of Jacob for ever; and of his kingdom there shall be no end. {1:34} Then said Mary unto the angel, How shall this be, seeing I know not a man? {1:35} And the angel answered and said unto her, The Holy Ghost shall come upon thee, and the power of the Highest shall overshadow thee: therefore also that holy thing which shall be born of thee shall be called the Son of God.”

It is interesting to note that the first time we meet the serpent (Satan) in the Bible he tells a lie.  John refers to our verse when Christ is talking about Satan’s origin and the Scribes and Pharisees:

Ye are of your father the devil, and the lusts of [your] father ye will do. He was a murderer from the beginning, and abode not in the truth, because there is no truth in him. When he speaketh a lie, he speaketh of his own: for he is a liar, and the father of it.

And finally, Paul reiterates that Satan has made a fatal mistake in thinking he could kill the Christ and prevent that saving of mankind, thus hearkening all the way back to Genesis 3:15:

{16:17} Now I beseech you, brethren, mark them which cause divisions
and offences contrary to the doctrine which ye have learned; and avoid
them. {16:18} For they that are such serve not our Lord Jesus Christ,
but their own belly; and by good words and fair speeches deceive the
hearts of the simple. {16:19} For your obedience is come abroad unto
all [men.] I am glad therefore on your behalf: but yet I would have you
wise unto that which is good, and simple concerning evil. {16:20} And
the God of peace shall bruise Satan under your feet shortly. The grace
of our Lord Jesus Christ [be] with you. Amen.” — Romans

Caravaggio_-_The_Annunciation

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